The study found increased DNA-directed DNA polymerase activity in RA synovial cells but no evidence of oncornavirus RNA-directed DNA polymerase activity.
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Does not support oncornavirus role in RA; hypothesis-generating for DNA polymerase activity in synovial cells.
Cultured synovial cells from 8 patients with rheumatoid arthritis (RA) and 7 subjects without joint disease were assayed and comapred for RNA-directed and DNA-directed DNA polymerase activity. No activity was found in either RA or control specimens using a synthetic RNA template that specificically detects oncornavirus RNA-directed DNA polymerase. The DNA-directed DNA polymerase activity of RA specimens was increased (P less than 0.10) in the high-speed pellet fraction of cell lysates. The possible relationship of these finding to virus infection in RA is disscussed.
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Spruance et al. (1975) studied this question.
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