The study weakens previous evidence suggesting the presence of an agent within rheumatoid synovial cells capable of producing intrinsic interference.
No support for intrinsic interference in RA synovial cells; weakens prior hypotheses and leaves viral role in pathogenesis open.
Nine rheumatoid and 5 control synovial cell cultures showed no deficiency in ability to grow rubella virus or to exhibit a cytopathic effect. This finding considerably weakens previous evidence arguing for the presence of an agent within rheumatoid synovial cells capable of producing intrinsic interference.
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Runge et al. (1972) studied this question.
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