Why the study?
Is there evidence of viral infection in specimens from patients with rheumatoid arthritis and other connective tissue diseases?
Is there evidence of viral infection in specimens from patients with rheumatoid arthritis and other connective tissue diseases?
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This study found no evidence to implicate a viral etiology in the pathogenesis of rheumatoid arthritis or other connective tissue diseases using cell culture methods.
A total of 187 specimens from 142 subjects with rheumatoid arthritis, systemic lupus erythematosus, other connective tissue diseases, and controls were placed in cell culture. Specimens from 119 of the subjects grew, lasting over 2 yr in several instances. No evidence of virus infection has been found by a variety of sensitive methods, including cell fusion. Other approaches have likewise failed thus far to implicate any virus in the pathogenesis of rheumatoid arthritis.
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Paul E. M. Phillips (1971) studied this question.
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