A chronic erosive arthritis was produced in rabbits by a single intraarticular injection of herpes simplex virus. Three months after injection, a moderate or severe arthritis was present in the injected knees of all 10 animals; mild or moderate changes were present in 9 of the contralateral (noninjected) knee joints. The histologic changes resemble those of human rheumatoid arthritis. Thus, under certain circumstances, a single exposure to herpes simplex virus appears to provoke chronic arthritis.
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Webb et al. (1973) studied this question.
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