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May 25, 2004Journal of Applied Physiology

Mechanisms of vasoactive intestinal peptide-mediated vasodilation in human skin

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Why the study?

What is the relative contribution of nitric oxide and histamine to VIP-mediated vasodilation in human skin?

Population

43 human subjects

Comparison

Vasoactive intestinal peptide infusions via… vs VIP alone or different inhibition states

Design

Other

Authors

BWBrad W. WilkinsVascular MedicineLCLinda H. ChungUniversidad Católica de MurciaNTNathan J. TublitzUniversity of Oregon

Discussion

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Implication

Hypothesis-generating for cutaneous VIP mechanisms; leaves open translation to systemic vascular disease or therapy.

Structured PICO

What is the relative contribution of nitric oxide and histamine to VIP-mediated vasodilation in human skin?

P
Population
43 human subjects
I
Intervention
Vasoactive intestinal peptide (VIP) infusions (25 to 800 pmol) via intradermal microdialysis, with or without NO synthase inhibition, H1-receptor inhibition, or H2-receptor inhibition
C
Comparator
VIP alone or different inhibition states (NO synthase inhibition, H1-receptor inhibition, H2-receptor inhibition)
O
Outcome
Cutaneous vascular conductance (CVC) and red blood cell fluxsurrogate

In human skin, VIP-mediated vasodilation involves both a NO-dependent component and H1-receptor activation, which operate independently.

Cite This Study

Wilkins et al. (2004) studied this question.

synapsesocial.com/papers/6a83f8edfd07e211f9fe241bhttps://doi.org/10.1152/japplphysiol.00366.2004
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predominant role for nitric oxide in the relaxation induced by vasoactive intestinal polypeptide in human uterine artery1998 · 38 citations
  2. 2Role of nitric oxide in the vascular effects of local warming of the skin in humans1999 · 460 citations
  3. 3Studies on pruritogenic and histamine-releasing effects of some putative peptide neurotransmitters1981 · 123 citations
  4. 4The Effect of the Nitric Oxide Synthase Inhibitor N-Nitro-<i>L</i>-Arginine-Methyl Ester on Neuropeptide-Induced Vasodilation and Protein Extravasation in Human Skin2003 · 52 citations