Population
Cultured endothelial cells of human umbilical cord veins (HUVEC)
Comparison
Basic fibroblast growth factor 50 ng/ml and/or… vs Untreated cells or cells treated with bFGF alone
Design
Preclinical
Follow-up
7 days
Authors
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Should not change practice; hypothesis-generating for Ca2+-activated K+ channel role in angiogenesis.
Blockade of Ca2+-activated K+ channels with iberiotoxin significantly inhibits bFGF-induced proliferation of human endothelial cells, suggesting a role in angiogenesis and vascular remodeling.
Wiecha et al. (1998) studied this question.
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