Why the study?
Does intravenous prostaglandin E2 alter platelet function, coagulation, and fibrinolysis in women?
Does intravenous prostaglandin E2 alter platelet function, coagulation, and fibrinolysis in women?
Intravenous PGE2 diminishes platelet adhesiveness and increases fibrinolytic activity, suggesting a potential physiological role in the prevention of thrombosis.
Answers are grounded in this paper and cite their sources.
PGE2 effects on platelets and fibrinolysis should not yet change practice; leaves open a physiological antithrombotic role in women.
Prostaglandin E(2) (PGE(2)) was infused intravenously to eight women for the termination of pregnancy and tests of platelet function: coagulation and fibrinolysis were studied before and during the infusion.Platelet adhesiveness, as measured by a cellophane membrane test-cell system, was significantly diminished by PGE(2), a change which was not noted by the glass-bead column technique. The administration of PGE(2) caused more rapid platelet disaggregation following ADP-induced aggregation but had no effect on the platelet count, collagen-induced aggregation, or platelet factor 3 activity. An increase in plasma antithrombin concentration and euglobulin lysis activity was also noted. These results support the concept that prostaglandin E(2) might have a role in the prevention of thrombosis.
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Howie et al. (1973) studied this question.
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