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June 21, 1965JAMA

Sudden Death During Treatment With Phenothiazine Derivatives

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Authors

LHLeo E. HollisterUniversity of Southern California

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Implication

Case series reports sudden death from ventricular fibrillation in psychiatric patients receiving phenothiazines, indicating severe cardiac risks linked to high-dose regimens.

Key Points

  • To describe clinical and postmortem characteristics of unexplained sudden deaths occurring in psychiatric patients receiving phenothiazine derivatives.
  • Clinical and postmortem evaluation of six otherwise healthy psychiatric patients who died suddenly while receiving standard high doses of phenothiazine derivatives.
  • Review of terminal event symptomatology and monitoring data during emergency resuscitation.
  • All six patients experienced a sudden syncopal-seizure episode followed immediately by cessation of respiration and heartbeat, with postmortem examinations failing to explain the deaths.
  • Irreversible ventricular fibrillation was documented during temporary resuscitation in one patient, indicating that lethal cardiac arrhythmia is the probable primary mechanism of mortality.

Cite This Study

Leo E. Hollister (1965) studied this question.

synapsesocial.com/papers/6a83fa7a53408ed95e4d92cdhttps://doi.org/10.1001/jama.1965.03080250013003
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