Population
Anesthetized rats instrumented with a Doppler flow probe on the superior mesenteric artery and an adjustable…
Comparison
Infusion of angiotensin II or phenylephrine vs Different local perfusion pressures
Design
Preclinical
Authors
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Does not yet alter clinical vasoconstrictor use; extends animal evidence on MAP-driven autoregulation and warrants translational studies.
Systemic vasoconstrictor infusion increases mean arterial pressure, which in turn stimulates autoregulation to further amplify local vascular resistance.
Meininger et al. (1988) studied this question.
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