March 1, 1990AJP Heart and Circulatory Physiology

Flow-induced resistance artery tone: balance between constrictor and dilator mechanisms

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Why the study?

Does flow-induced infusion of physiological saline solution change resistance artery tone in isolated rabbit ear arteries?

Population

Isolated segments of small rabbit ear arteries (approximately 200 microns OD)

Comparison

Infusion of physiological saline solution into… vs Different levels of baseline wall tone set by…

Design

Preclinical

Authors

JBJohn A. BevanUniversity of Vermont EJElizabeth H. JoyceStanford University

Discussion

Member takes

Implication

Does not support clinical application; leaves open translation of tone-dependent flow responses to human vessels.

Structured PICO

Does flow-induced infusion of physiological saline solution change resistance artery tone in isolated rabbit ear arteries?

Population

Isolated segments of small rabbit ear arteries (approximately 200 microns OD)

Intervention

Infusion of physiological saline solution into the lumen at 35 microliters/min

Comparator

Different levels of baseline wall tone set by norepinephrine

Outcome

Change in resistance artery tone (flow-induced relaxation or constriction)surrogate

Flow-induced changes in resistance artery tone appear to result from a balance between independent constrictor and dilator influences depending on the baseline wall tone.

Cite This Study

Bevan et al. (1990) studied this question.

synapsesocial.com/papers/6a83fac4d65172829ee670c1 https://doi.org/10.1152/ajpheart.1990.258.3.h663

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Flow-induced resistance artery tone: balance between constrictor and dilator mechanisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Flow-induced resistance artery tone: balance between constrictor and dilator mechanisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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