July 1, 1990AJP Heart and Circulatory Physiology

Saline infusion into lumen of resistance artery and small vein causes contraction

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Population

Rabbit resistance arteries and small ear veins

Design

Preclinical

Authors

JBJohn A. BevanUniversity of Vermont EJElizabeth H. JoyceStanford University

Discussion

Member takes

Implication

Suggests shear stress directly activates vascular smooth muscle; hypothesis-generating and requires validation in intact human vessels.

Structured PICO

Population

Rabbit resistance arteries (pial, ear/skin, femoral/muscle, coronary, mesenteric, renal, and pulmonary segments) and small ear veins

Intervention

Saline infusion into the lumen at rates between 0.5 and 20 microliters/min

Outcome

Vessel contractionsurrogate

Saline flow-induced shear stress mechanically activates vascular smooth muscle cells, causing an extracellular calcium-dependent contraction in resistance arteries.

Cite This Study

Bevan et al. (1990) studied this question.

synapsesocial.com/papers/6a8bd57ade5ec4e001e3d83c https://doi.org/10.1152/ajpheart.1990.259.1.h23

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Ask AI

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Saline infusion into lumen of resistance artery and small vein causes contraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Saline infusion into lumen of resistance artery and small vein causes contraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider