Why the study?
Having previously reported decreased canstatin in the infarcted area after myocardial infarction, the authors sought to investigate the regulatory mechanism for the expression of arresten and canstatin.
Cathepsin S degrades basement membrane-derived endogenous factors arresten and canstatin in the infarcted area immediately after myocardial infarction in rats.
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Cathepsin S inhibition may preserve anti-angiogenic factors post-MI; hypothesis-generating in rodents only.
Sugiyama et al. (2019) studied this question.
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