Population
Unanesthetized and anesthetized dogs
Comparison
6-hydroxydopamine (total dose 50 mg/kg) vs Normal dogs and baseline measurements
Design
Preclinical
Follow-up
3 days
Authors
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6-Hydroxydopamine induces effective canine sympathectomy; extends autonomic models for cardiovascular research while leaving human translation open.
6-hydroxydopamine effectively induces generalized chemical sympathectomy in dogs, providing a useful model for studying the autonomic nervous system's role in cardiovascular regulation.
Gauthier et al. (1972) studied this question.
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