May 31, 2006Journal of Immunoassay and Immunochemistry

Clinical Evaluation of Point‐of‐Care‐Testing of Heart‐Type Fatty Acid‐Binding Protein (H‐FABP) for the Diagnosis of Acute Myocardial Infarction

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Why the study?

Does point-of-care testing of H-FABP improve the early diagnosis of acute myocardial infarction compared to conventional cardiac markers?

Population

83 patients, including those with confirmed acute myocardial infarction, non-AMI cardiac diseases, and…

Comparison

Point-of-care-testing of heart-type fatty… vs Conventional cardiac biochemical markers.

Design

Cross-sectional

Authors

TTTakao TanakaSuntory Foundation for Life Sciences KSKoichi SohmiyaKameda Medical Center YKYasushi KitauraOsaka Medical and Pharmaceutical University

Discussion

Member takes

Implication

H-FABP may aid superacute AMI detection but risks false positives; cross-sectional data leave POC utility versus troponin open.

Structured PICO

Does point-of-care testing of H-FABP improve the early diagnosis of acute myocardial infarction compared to conventional cardiac markers?

Population

83 patients, including those with confirmed acute myocardial infarction (AMI) (n=53), non-AMI cardiac diseases (n=24), and non-cardiac diseases with chest pain (n=6).

Intervention

Point-of-care-testing (POCT) of heart-type fatty acid-binding protein (H-FABP) using 150 microL of whole blood, read within 15 minutes.

Comparator

Conventional cardiac biochemical markers (myoglobin, creatine kinase isoenzyme MB [CK-MB], and cardiac troponin T).

Outcome

Diagnostic sensitivity and specificity for acute myocardial infarction in the superacute phase (within 3 hours).surrogate

Point-of-care testing for H-FABP provides high sensitivity but lower specificity compared to troponin T for detecting acute myocardial infarction within 3 hours of onset.

Cite This Study

Tanaka et al. (2006) studied this question.

synapsesocial.com/papers/6a83fbe5403dcf0d873c29e5 https://doi.org/10.1080/15321810600734919

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Clinical Evaluation of Point‐of‐Care‐Testing of Heart‐Type Fatty Acid‐Binding Protein (H‐FABP) for the Diagnosis of Acute Myocardial Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Clinical Evaluation of Point‐of‐Care‐Testing of Heart‐Type Fatty Acid‐Binding Protein (H‐FABP) for the Diagnosis of Acute Myocardial Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider