Why the study?
Does chronic reversible ischemia (hibernating myocardium) impair sympathetic nerve function in a swine model?
Population
Swine chronically instrumented with a left anterior descending coronary artery stenosis producing…
Comparison
LAD stenosis to produce hibernating myocardium vs Normal remote regions and sham-instrumented…
Design
Preclinical
Follow-up
3 months
Authors
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Sympathetic impairment in hibernating myocardium may heighten arrhythmia risk; leaves open clinical relevance pending human studies.
Does chronic reversible ischemia (hibernating myocardium) impair sympathetic nerve function in a swine model?
The sympathetic norepinephrine uptake-1 mechanism is impaired in hibernating myocardium, suggesting a potential mechanism for the increased risk of sudden death and lethal arrhythmias in this setting.
Luísi et al. (2002) studied this question.
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