November 1, 1995Annual Review of Cell and Developmental Biology
Nitric Oxide: A Neural Messenger
Design
Review
Authors
Discussion
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Implication
Reinforces nitric oxide's established neurotransmitter roles; leaves open targeted therapies for its effects in stroke and neurodegeneration.
Key Points
- Summarize the physiological identity of nitric oxide as a neural messenger and its functional significance across the nervous system.
- Synthesized evidence from pharmacological, immunohistochemical, and biochemical investigations of nitric oxide and cGMP signaling.
- Evaluated autonomic and behavioral outcomes derived from targeted nitric oxide synthase knockout mouse models.
- Nitric oxide mediates cGMP accumulation following glutamatergic stimulation, confirming its status as an atypical neurotransmitter in central and peripheral nerves.
- Knockout mouse models demonstrate that nitric oxide signaling is indispensable for normal behavioral and autonomic regulation.
- Nitric oxide exerts bidirectional neuroprotective and neurotoxic actions, contributing to the pathogenesis of stroke and neurodegenerative conditions.
Cite This Study
Jaffrey et al. (1995) studied this question.