October 1, 2000British Journal of PharmacologyOpen Access

Evidence for VIP1/PACAP receptors in the afferent pathway mediating surgery‐induced fundic relaxation in the rat

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Population

Rats undergoing abdominal surgery (manipulation of the small intestine followed by resection of the caecum)

Design

Preclinical

Authors

GBGuy E. BoeckxstaensRoyal Adelaide Hospital MHMarkus W. HollmannNorthwestern University SHS. H. HeisterkampUniversity of Groningen

Discussion

Member takes

Implication

Hypothesis-generating in rat ileus model; leaves open whether VIP1 antagonism affects human perioperative motility.

Structured PICO

Population

Rats undergoing abdominal surgery (manipulation of the small intestine followed by resection of the caecum)

Intervention

L-NOARG (NO biosynthesis inhibitor), non-selective VIP receptor antagonist, and selective VIP(1) receptor antagonist

Outcome

Non-adrenergic fundic relaxationsurrogate

The NANC inhibitory pathway activated during abdominal surgery in rats involves VIP(1) receptors in the afferent limb, with NO and a non-VIP substance acting as inhibitory neurotransmitters at the smooth muscle.

Cite This Study

Boeckxstaens et al. (2000) studied this question.

synapsesocial.com/papers/6a84053cdc9bcdcbf8c6b3ab https://doi.org/10.1038/sj.bjp.0703625

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Evidence for VIP1/PACAP receptors in the afferent pathway mediating surgery‐induced fundic relaxation in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for VIP1/PACAP receptors in the afferent pathway mediating surgery‐induced fundic relaxation in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider