Low Dietary Sodium and Exogenous Angiotensin II Infusion Decrease Plasma Adiponectin Concentrations in Healthy Men
Why the study?
Does physiological and pharmacological modulation of the RAAS affect plasma adiponectin concentrations in healthy men?
Population
35 healthy male volunteers, mean age 26 +/- 9 years
Comparison
Physiological modulation and pharmacological… vs Baseline states and contrasting RAAS modulation…
Follow-up
7-day periods
Authors
Discussion
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Implication
RAAS modulation affects adiponectin in healthy men; hypothesis-generating for vascular benefits of ACE inhibitors, needs confirmation in patients.
Structured PICO
Does physiological and pharmacological modulation of the RAAS affect plasma adiponectin concentrations in healthy men?
P
Population
35 healthy male volunteers, mean age 26 +/- 9 years
I
Intervention
Physiological modulation (low-sodium diet 50 mmol/day vs high-sodium diet 200 mmol/day for 7 days) and pharmacological modulation (angiotensin II infusion 0.3, 1, and 3 ng/kg.min for 1 hour; enalapril 20 mg once daily for 1 week) of the renin-angiotensin aldosterone system (RAAS)
C
Comparator
Baseline states and contrasting RAAS modulation states (low vs high sodium, pre- vs post-infusion/treatment)
O
Outcome
Plasma adiponectin concentrations during low-sodium and high-sodium diets and in response to angiotensin II infusionsurrogate
RAAS activation (via low sodium or angiotensin II) decreases plasma adiponectin, while RAAS blockade (enalapril) increases it, suggesting a potential mechanism for the vascular benefits of RAAS inhibitors.
Cite This Study
Lely et al. (2007) studied this question.