The arterial pressure response to serotonin is highly variable and depends on a complex interplay of four main physiological actions influenced by dose, species, and baseline neurogenic tone.
Serotonin's variable pressor effects limit direct clinical extrapolation; leaves open species- and dose-specific mechanisms for targeted human studies.
Arterial pressure response to serotonin depends largely upon four main actions of the drug: direct vasoconstriction, a von Bezold-like reflex, transient ganglion blockade and peripheral inhibition of neurogenic vasoconstriction. The relative prominence of these actions differs depending upon the dose of serotonin, species tested and degree of pre-existing neurogenic vasoconstriction.
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Page et al. (1953) studied this question.
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