Why the study?
Does participation in a long-distance run cause myocardial injury as measured by cardiac biomarkers in elderly athletes without coronary artery disease?
Does participation in a long-distance run cause myocardial injury as measured by cardiac biomarkers in elderly athletes without coronary artery disease?
Long-distance running in elderly athletes without coronary artery disease does not cause myocardial injury, as evidenced by normal cardiac troponin I levels despite increases in CPK and CK-MB.
Answers are grounded in this paper and cite their sources.
Supports no myocardial injury from long-distance running in elderly athletes without CAD; leaves open larger prospective studies.
Elderly population often is encouraged to practice sports in preventing cardiovascular diseases. However, evidences exist that intense physical efforts are related with a higher risk for acute myocardial infarction and sudden death. Biological markers for myocardial injury was analyzed in a group of 15 elderly athletes without a history of coronary artery disease, who participated in the 77th International Sao Silvestre race (15,000 m) in Sao Paulo City. A statistical difference was observed between total CPK activity levels before the run, immediately after the run, and some time later. Similar results were observed in the concentration of CK-MB mass. The cardiac troponin I (TnI-c) levels remained unchanged and within normal limits during the same time periods. The results of the present study showed no evidence of myocardial injury in elderly subjects without a history of coronary artery disease after participating in long-distance runs, as confirmed by the analysis of TnI-c levels. The increase in total CPK activity levels and the concentration of CK-MB mass do not represent myocardial injury in these subjects.
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Souza et al. (2006) studied this question.
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