Why the study?
Hyperbaric bupivacaine causes cardiotoxicity and high sympathetic blocks in parturients, whereas isobaric levobupivacaine may provide adequate sensory block with fewer hemodynamic changes and reduced cardiovascular toxicity.
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Population
Parturients undergoing elective LSCS
Comparison
Intrathecal 0.5% isobaric levobupivacaine vs 0.5% hyperbaric bupivacaine with fentanyl 25 µg
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May reduce hemodynamic instability during cesarean spinal anesthesia; leaves open whether levobupivacaine improves outcomes versus bupivacaine.
Rao et al. (2020) studied this question.
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