January 1, 1998HypertensionOpen Access

Role of Endogenous Nitric Oxide in the Brain Stem on the Rapid AdaptatKion of Baroreflex

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Population

Anesthetized rabbits with isolated bilateral carotid sinuses

Comparison

Intracisternal injection of N-nitro-L-arginine… vs Intracisternal injection of vehicle solution

Design

Preclinical

Authors

KHKiyoshi HironagaFukuoka City Hospital YHYoshitaka HirookaGeneral Cardiology IMIsamu MatsuoKobe City College of Technology

Discussion

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Implication

No immediate clinical implications; extends preclinical evidence on brainstem nitric oxide in baroreflex sympathetic control.

Structured PICO

Population

Anesthetized rabbits with isolated bilateral carotid sinuses

Intervention

Intracisternal injection of N(omega)-nitro-L-arginine methyl ester (L-NAME, 8 micromol), N(omega)-nitro-D-arginine methyl ester (D-NAME, 8 micromol), or L-arginine (40 micromol)

Comparator

Intracisternal injection of vehicle solution

Outcome

Magnitude of immediate and maximal inhibition of renal sympathetic nerve activity and its rate of recovery following a stepwise increase in carotid sinus pressuresurrogate

Endogenous nitric oxide in the brain stem attenuates the rapid adaptation of arterial baroreflex control of sympathetic nerve activity.

Cite This Study

Hironaga et al. (1998) studied this question.

synapsesocial.com/papers/6a840a2d002ab1506fb2939f https://doi.org/10.1161/01.hyp.31.1.27

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Role of Endogenous Nitric Oxide in the Brain Stem on the Rapid AdaptatKion of Baroreflex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of Endogenous Nitric Oxide in the Brain Stem on the Rapid AdaptatKion of Baroreflex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider