Parathyroid hormone-related peptide improves contractile function of stunned myocardium in rats and pigs

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Population

11 anesthetized pigs, myocytes isolated from stunned pig hearts, and isolated rat hearts subjected to…

Comparison

Intracoronary infusion of synthetic parathyroid… vs Baseline function / unblocked state

Design

Preclinical

Authors

Discussion

Does not alter clinical management of stunning; leaves open PTHrP's therapeutic role pending human studies.

Population

11 anesthetized pigs, myocytes isolated from stunned pig hearts, and isolated rat hearts subjected to ischemia-reperfusion

Intervention

Intracoronary infusion of synthetic parathyroid hormone-related peptide [PTHrP(1-34)] and blockade of endogenous PTHrP by d-Trp(12)-Tyr(34)-PTH(7-34)

Comparator

Baseline function / unblocked state

Outcome

Regional myocardial function and coronary resistancesurrogate

Endogenous and exogenous PTHrP improve the contractile function of stunned myocardium following ischemia-reperfusion.

Jansen et al. (2003) studied this question.

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