The influence of feeding either fat and lipase or lecithin on the sugar excretion of depancreatised dogs

AN extensive investigation of the metabolism of the phloridzinised dog has led Graham Lusk and co-workers to conclude, by analogy, that the metabolic disturbance in diabetes mellitus and in depancreatised dogs, due to the relative or complete lack of insulin, is a corresponding inability to oxidise carbohydrates. On the basis of this interpretation, these workers have strenuously opposed the view that sugar may be derived from fatty acid in the animal organism. The recent work of Wierzuchowski [1926], confirmed by Deuel, Wilson and Milhorat [1927], which demonstrated the oxidation of glucose by the phloridzinised dog, casts considerable doubt upon the above interpretation of the diabetic state.