What question did this study set out to answer?

To examine the effects of alloxan-induced diabetes, starvation, fatty acids, and ketone bodies on pyruvate metabolism and metabolite ratios in rat heart and diaphragm muscles.

December 1, 1964Biochemical JournalOpen Access

Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation, on pyruvate metabolism and on lactate-pyruvate and l-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscles

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Authors

PGP. B. GarlandUniversity of Cambridge ENE. A. NewsholmeUniversity of Oxford RPRandle PjUniversity of Cambridge

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Implication

Experimental study demonstrates impaired pyruvate uptake and oxidation in diabetic rat muscle, indicating disrupted metabolic regulation in diabetes.

Key Points

To examine the effects of alloxan-induced diabetes, starvation, fatty acids, and ketone bodies on pyruvate metabolism and metabolite ratios in rat heart and diaphragm muscles.
Measured pyruvate uptake, oxidation rates, and lactate output in slices of ventricle muscle and intact diaphragm muscle isolated from rats with alloxan diabetes.
Assessed changes in carbohydrate metabolism and metabolite concentration ratios in response to altered metabolic states.
Ventricle muscle slices and diaphragm muscle from rats with alloxan-induced diabetes exhibit impaired uptake and oxidation of pyruvate.
Diabetic muscle tissues demonstrate increased output of lactate relative to normal tissue controls.

Cite This Study

Garland et al. (1964) studied this question.

synapsesocial.com/papers/6a75d14e20e137e1c11626eb https://doi.org/10.1042/bj0930665

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Implication

Experimental study demonstrates impaired pyruvate uptake and oxidation in diabetic rat muscle, indicating disrupted metabolic regulation in diabetes.

Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation, on pyruvate metabolism and on lactate-pyruvate and l-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscles

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Key Points

Cite This Study

Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation, on pyruvate metabolism and on lactate-pyruvate and l-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscles

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Cite This Study

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