December 1, 1996AJP Heart and Circulatory Physiology
Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work
Why the study?
Does diabetes impair myocardial glucose uptake and pyruvate oxidation under normal conditions and during dobutamine-induced work in a micropig model?
Population
Streptozotocin-diabetic micropigs (n=8) and nondiabetic control micropigs (n=8)
Comparison
Dobutamine infusion to induce increased cardiac… vs Nondiabetic control group infused with…
Design
Preclinical
Authors
Discussion
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Implication
Pyruvate oxidation defect may predominate over glucose uptake impairment in diabetic myocardium during stress; hypothesis-generating in micropig model and requires human confirmation.
Structured PICO
Does diabetes impair myocardial glucose uptake and pyruvate oxidation under normal conditions and during dobutamine-induced work in a micropig model?
P
Population
Streptozotocin-diabetic micropigs (n=8) and nondiabetic control micropigs (n=8)
I
Intervention
Dobutamine infusion to induce increased cardiac work
C
Comparator
Nondiabetic control group infused with triglyceride emulsion, glucose, and somatostatin to create an acute diabetic-like state
O
Outcome
Myocardial glucose uptake and pyruvate oxidationsurrogate
The major derangement in carbohydrate metabolism in the diabetic myocardium is impaired pyruvate oxidation rather than glycolysis, even during increased cardiac work.
Cite This Study
Hall et al. (1996) studied this question.