The asymmetric aldol reaction of 4-trimethylsiloxy-6-methylene-1,3dioxines or the 6ethylidene analogue with achiral aldehydes proceeds in a highly enantioselective manner under chual binaphthol-titanium complex catalysis to afford dsubstituted 1,3-dioxin-4-ones which serve as chemical equivalents of 6-hydroxy-P-keto esters, potential chiral building blocks.An explanation for the stereoselectivity is also presented.
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Kaneko et al. (1995) studied this question.