Key result
Having three or more prior open-heart surgeries before surgical pulmonary valve replacement significantly increased the risk of overall mortality (HR 13.856) in patients with congenital heart disease.
Why the study?
To establish the long-term outcome of surgical pulmonary valve replacement in congenital heart disease and identify risk factors for overall mortality, operative mortality, and repetitive pulmonary valve replacement.
Cohort (n=293)
No
Hazard Ratio: 13.856 (95% CI 3.519–54.555)
p-value: p=<0.001
Surgical pulmonary valve replacement in congenital heart disease has excellent long-term survival, but mortality risk is significantly elevated in patients with three or more prior open-heart surgeries.
May warrant heightened surveillance in patients with ≥3 prior surgeries; leaves open whether surgical history is causal or a surrogate for disease complexity.
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Park et al. (2022) conducted a cohort in Congenital heart disease (n=293). Prior open-heart surgery (≥3 times) vs. <3 prior open-heart surgeries was evaluated on Overall mortality (HR 13.856, 95% CI 3.519-54.555, p=<0.001). Having three or more prior open-heart surgeries before surgical pulmonary valve replacement significantly increased the risk of overall mortality (HR 13.856) in patients with congenital heart disease.
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