Why the study?
Does pindolol alter transmembrane action potentials and automaticity in isolated canine cardiac fibers?
Population
Isolated perfused cardiac fibers from mongrel dogs anesthetized with intravenous thiamylal sodium.
Comparison
Pindolol added to perfusate, alone or in… vs Control state.
Design
Preclinical
Authors
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Supports beta-blockade primacy for pindolol antiarrhythmia in isolated fibers; leaves open translation to clinical arrhythmias.
Does pindolol alter transmembrane action potentials and automaticity in isolated canine cardiac fibers?
The antiarrhythmic action of pindolol is primarily mediated by its beta-adrenergic blocking properties rather than direct membrane depressant effects, which only occur at concentrations far exceeding therapeutic levels.
Shimizu et al. (1978) studied this question.
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