Population
Saponin-treated rat cardiac trabeculae
Comparison
2,3-butanedione monoxime at various concentrations vs Before and after exposure to BDM
Design
Preclinical
Authors
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Animal data on BDM's SR Ca2+ effects; leaves open translation to intact hearts or clinical use.
BDM exerts a negative inotropic effect at high concentrations by reducing the amount of Ca2+ available for release from the sarcoplasmic reticulum during systole.
Steele et al. (1993) studied this question.
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