May 19, 2001Acta Physiologica ScandinavicaOpen Access

2,3‐Butanedione monoxime increases speed of relaxation in single muscle fibres of frog

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Population

Single muscle fibres from the anterior tibialis muscle of Rana temporaria (frog)

Comparison

2,3-butanedione monoxime at concentrations of… vs Standard Ringer solution (control conditions)

Design

Preclinical

Authors

YSYin‐Biao SunHeart Failure / Cardiomyopathy FLFang LouKunming University of Science and Technology KEK. A. P. EdmanLund University

Discussion

Member takes

Implication

Hypothesis-generating for cross-bridge modulation of relaxation; leaves open translation to mammalian or clinical muscle disorders.

Structured PICO

Population

Single muscle fibres from the anterior tibialis muscle of Rana temporaria (frog)

Intervention

2,3-butanedione monoxime (BDM) at concentrations of 1.0, 1.8, or 5.0 mM

Comparator

Standard Ringer solution (control conditions)

Outcome

Intracellular Ca2+ transient and cross-bridge function (force development and relaxation)surrogate

BDM increases the speed of relaxation and depresses force in frog skeletal muscle primarily by affecting cross-bridge kinetics rather than intracellular calcium transients.

Cite This Study

Sun et al. (2001) studied this question.

synapsesocial.com/papers/6a986c3d3facabbc5fd4af3e https://doi.org/10.1046/j.1365-201x.2001.00818.x

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2,3‐Butanedione monoxime increases speed of relaxation in single muscle fibres of frog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

2,3‐Butanedione monoxime increases speed of relaxation in single muscle fibres of frog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider