Key result
Autonomic responses correlated with fatigue in MS patients, resembling a hypoadrenergic orthostatic response possibly due to a sympathetic vasomotor lesion.
Observational (n=60)
Fatigue in multiple sclerosis is associated with sympathetic vasomotor dysfunction, suggesting a potential therapeutic target for MS-associated fatigue.
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Sympathetic vasomotor dysfunction may contribute to MS fatigue; hypothesis-generating and requires prospective trials before clinical adoption.
The authors studied standard autonomic function tests and measures of heart rate variability in 60 patients with multiple sclerosis (MS) and correlated results with the Fatigue Severity Scale and the Modified Fatigue Impact Scale. The authors found that autonomic responses correlated with fatigue resembling a hypoadrenergic orthostatic response, possibly due to a sympathetic vasomotor lesion with intact vagal heart control. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study.
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Flachenecker et al. (2003) conducted an observational in Multiple sclerosis (MS) (n=60). Sympathetic vasomotor dysfunction was evaluated on Correlation between autonomic responses and fatigue (Fatigue Severity Scale and Modified Fatigue Impact Scale). Autonomic responses correlated with fatigue in MS patients, resembling a hypoadrenergic orthostatic response possibly due to a sympathetic vasomotor lesion.
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