Key result
Subjects in the highest tertiles of circulating ANGPTL8 had significantly higher odds of having metabolic syndrome (OR 2.3) independent of age, gender, ethnicity, and HsCRP levels.
Cross-Sectional (n=1,735)
Odds Ratio: 2.3 (95% CI 1.6–3.1)
p-value: p=<0.0001
Circulating ANGPTL8 levels are significantly elevated in individuals with metabolic syndrome and correlate positively with HsCRP, suggesting a potential role in metabolic and inflammatory pathways.
Elevated ANGPTL8 was associated with metabolic syndrome; hypothesis-generating and should not yet change practice.
BACKGROUND: ANGPTL8 also called betatrophin is a regulator of lipid metabolism through its interaction with ANGPTL3. It has also been suggested to play a role in insulin resistance and beta-cell proliferation. Based on its function, we hypothesized that ANGPTL8 will play a role in Metabolic Syndrome (MetS). To test this hypothesis we designed this study to measure ANGPTL8 level in subjects with MetS as well as its association with high sensitivity C-reactive protein (HsCRP) level in humans. METHODS: ANGPTL8 level was measured using ELISA in subjects with MetS as well as their controls, a total of 1735 subjects were enrolled. HsCRP was also measured and its association with ANGPTL8 was examined. RESULTS: ANGPTL8 level was higher in subjects with MetS 1140.6 (171.9-11736.1) pg/mL compared to 710.5 (59.5-11597.2) pg/mL in the controls. Higher levels of ANGPTL8 were also observed with the sequential increase in the number of MetS components (p value = <0.0001). ANGPTL8 showed strong positive correlation with HsCRP (r = 0.15, p value = <0.0001). Stratifying the population into tertiles according to the level of HsCRP showed increased ANGPTL8 level at higher tertiles of HsCRP in the overall population (p value = <0.0001).A similar trend was also observed in MetS and non-MetS subjects as well as in non-obese and obese subjects. Finally, multiple logistic regression models adjusted for age, gender, ethnicity and HsCRP level showed that subjects in the highest tertiles of ANGPTL8 had higher odds of having MetS (odd ratio [OR] = 2.3, 95 % confidence interval [CI] = (1.6-3.1), p value <0.0001. CONCLUSION: In this study we showed that ANGPTL8 is increased in subjects with MetS and it was significantly associated with HsCRP levels in different subgroups highlighting its potential role in metabolic and inflammatory pathways.
No takes yet. Share an insight, caveat, or question.
Abu‐Farha et al. (2016) conducted a cross-sectional in Metabolic Syndrome (n=1,735). Elevated ANGPTL8 (betatrophin) levels vs. Lower tertiles of ANGPTL8 was evaluated on Odds of having Metabolic Syndrome (MetS) (OR 2.3, 95% CI 1.6-3.1, p=<0.0001). Subjects in the highest tertiles of circulating ANGPTL8 had significantly higher odds of having metabolic syndrome (OR 2.3) independent of age, gender, ethnicity, and HsCRP levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: