Long-term dietary supplementation with L-arginine prevents age-related reduction in renal function
Why the study?
Does long-term dietary supplementation with L-arginine prevent age-related reduction in renal function in rats?
Population
24 rats aged 12-13 months
Comparison
L-arginine (2% in 2.5% corn syrup) for 8 months vs Sodium nitrite, untreated control, or 2.5% corn…
Design
Preclinical
Follow-up
8 months
Authors
Discussion
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Implication
May warrant human trials of L-arginine for age-related renal decline; leaves open translation beyond rats.
Structured PICO
Does long-term dietary supplementation with L-arginine prevent age-related reduction in renal function in rats?
P
Population
24 rats aged 12-13 months
I
Intervention
L-arginine (2% in 2.5% corn syrup) for 8 months
C
Comparator
Sodium nitrite (0.1% in 2.5% syrup), untreated control, or 2.5% corn syrup
O
Outcome
Renal function (urinary protein, urinary nitrate/nitrite, GFR, glomerular morphology)surrogate
Long-term dietary supplementation with L-arginine prevents age-related glomerular injury and reduction in GFR in rats, potentially independent of NO.
Cite This Study
Reckelhoff et al. (1997) studied this question.