Key result
Use of dihydropyridine calcium channel blockers was significantly associated with microalbuminuria in nondiabetic subjects (OR 1.76; 95% CI 1.22-2.54).
Why the study?
Do different antihypertensive drug classes influence microalbuminuria in non-diabetic subjects?
Observational (n=6,836)
Do different antihypertensive drug classes influence microalbuminuria in non-diabetic subjects?
Odds Ratio: 1.76 (95% CI 1.22–2.54)
Dihydropyridine calcium channel blockers are associated with increased microalbuminuria compared to other antihypertensives in non-diabetic subjects, suggesting they may not be the optimal choice if microalbuminuria reduction is a therapeutic goal.
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Dihydropyridine CCB use was associated with microalbuminuria in nondiabetic subjects; leaves open whether this reflects causation or confounding.
Monster et al. (2002) conducted an observational in Microalbuminuria in nondiabetic subjects (n=6,836). Dihydropyridine calcium channel blockers vs. Other antihypertensive drug groups or no antihypertensive was evaluated on Microalbuminuria (OR 1.76, 95% CI 1.22-2.54). Use of dihydropyridine calcium channel blockers was significantly associated with microalbuminuria in nondiabetic subjects (OR 1.76; 95% CI 1.22-2.54).
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