Key result
Jian Ling Decoction alone showed no blood pressure reduction compared to antihypertensive drugs, but significantly reduced blood pressure when combined with antihypertensive drugs.
Why the study?
Does Jian Ling Decoction alone or combined with antihypertensive drugs reduce blood pressure in patients with essential hypertension?
Systematic Review (n=655)
Does Jian Ling Decoction alone or combined with antihypertensive drugs reduce blood pressure in patients with essential hypertension?
Jian Ling Decoction combined with antihypertensive drugs may reduce blood pressure in essential hypertension, but current evidence is limited by poor methodological quality of available trials.
May support adjunctive use with antihypertensives; leaves open efficacy pending higher-quality trials.
OBJECTIVES: Jian Ling Decoction (JLD) is often prescribed to improve hypertension-related symptoms in China. However, this treatment has not been systematically reviewed for its efficacy against essential hypertension (EH). This review aims to assess the current clinical evidence of JLD in the treatment of EH. DESIGN: Seven electronic databases, including the Cochrane Central Register of Controlled Trials, PubMed, EMBASE, the Chinese National Knowledge Infrastructure (CNKI), the Chinese Scientific Journal Database (VIP), the Chinese Biomedical Literature Database (CBM) and the Wanfang Database, were searched up to March 2014. Randomised control trials (RCTs) comparing JLD or combined with antihypertensive drugs versus antihypertensive drugs were included. We assessed the methodological quality, extracted the valid data and conducted the meta-analysis according to criteria from the Cochrane group. The primary outcome was categorical or continuous blood pressure (BP), and the secondary outcome was quality of life (QOL). RESULTS: Ten trials (655 patients) with unclear-to-high risk of bias were identified. Meta-analysis showed that JLD used alone showed no BP reduction effect; however, improvement on QOL was found in the JLD group compared to antihypertensive drugs. A significant reduction in systolic and diastolic BP was observed for JLD plus antihypertensive drugs when compared with antihypertensive drugs alone. No serious adverse effects were reported. CONCLUSIONS: Owing to insufficient clinical data, it is difficult to draw a definite conclusion regarding the effectiveness and safety of JLD for EH, and better trials are needed.
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Xiong et al. (2015) conducted a systematic review in Essential hypertension (n=655). Jian Ling Decoction (JLD) alone or combined with antihypertensive drugs vs. Antihypertensive drugs was evaluated on Categorical or continuous blood pressure (BP). Jian Ling Decoction alone showed no blood pressure reduction compared to antihypertensive drugs, but significantly reduced blood pressure when combined with antihypertensive drugs.
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