The study suggests that phosphorylation and dephosphorylation of the myosin light chain are not the sole regulatory mechanisms for Ca2+ in smooth muscle.
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Hypothesis-generating for non-phosphorylation Ca2+ mechanisms in smooth muscle; leaves open human relevance and should not change practice.
Intimal myosin B considerably retained the Ca2+ in the presence of chlor promazine which inhibited the phosphorylation of myosin light chain. This result suggests that the phosphorylation and dephosphorylation of the 20,000-dalton light chain of myosin are not the sole regulatory mechanism in smooth muscle.
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Ken Ebisawa (1983) studied this question.
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