Why the study?
How does age affect the pharmacodynamics and disposition of verapamil in hypertensive male patients?
Population
24 hypertensive males (7 young, 10 elderly, and 7 very elderly)
Comparison
Verapamil vs Comparison between age groups
Design
Cohort
Authors
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May warrant verapamil dose caution in elderly hypertensives; leaves open need for prospective trials to guide age-adjusted regimens.
How does age affect the pharmacodynamics and disposition of verapamil in hypertensive male patients?
Verapamil clearance is decreased and half-life prolonged in elderly hypertensive patients, accompanied by altered hemodynamic and autonomic responses compared to young patients.
Schwartz et al. (1986) studied this question.
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