Key result
Ribosomes possess regulatory capabilities that affect mRNA translation efficiency through discrete binding interactions, such as the base-pairing of the HCV IRES to 18S rRNA.
Population
Ribosomes, mRNAs, and Hepatitis C Virus (HCV) internal ribosome entry site (IRES)
Design
Review
Authors
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May inform mRNA therapeutic design in cardiology; leaves open validation of ribosomal binding effects.
Ribosomes actively regulate mRNA translation efficiency through discrete binding interactions, such as the base-pairing between the HCV IRES and 18S rRNA.
Mauro et al. (2015) reported a review. Ribosomes possess regulatory capabilities that affect mRNA translation efficiency through discrete binding interactions, such as the base-pairing of the HCV IRES to 18S rRNA.
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