Key result
Binding of the human 40S ribosomal subunit to the HCV IRES involves specific exposed lysine residues on ribosomal proteins S27, S10, and S3a.
Population
Human 40S ribosomal subunit and its binary complexes with RNA transcripts corresponding to the full-size…
Comparison
Fluorescent labeling using the… vs Free 40S ribosomal subunits
Design
Preclinical
Authors
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Does not inform HCV therapy; leaves open whether these lysine residues represent druggable targets for IRES inhibition.
The study identifies specific lysine residues of ribosomal proteins S27, S10, and S3a that are involved in binding different domains of the hepatitis C virus IRES.
Malygin et al. (2013) studied Hepatitis C virus (HCV). Binding of HCV IRES RNA transcripts vs. Free 40S ribosomal subunits was evaluated on Modification levels of ribosomal proteins. Binding of the human 40S ribosomal subunit to the HCV IRES involves specific exposed lysine residues on ribosomal proteins S27, S10, and S3a.
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