Population
Poliovirus/Hepatitis C Virus (PV/HCV) chimera and dicistronic poliovirus replicons
Comparison
Genetic analysis and 5' deletion analyses of the… vs Parental poliovirus type 1 (Mahoney)
Design
Preclinical
Authors
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Refines HCV IRES domain II map in chimera model; leaves open native virus validation for therapeutic targeting.
The study successfully used a poliovirus/HCV chimera to map the 5' border of the HCV IRES to domain II and identify a novel structural region, overcoming difficulties in propagating HCV.
Zhao et al. (2001) studied this question.
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