cis-acting RNA elements required for replication of bovine viral diarrhea virus–hepatitis C virus 5′ nontranslated region chimeras
Population
Chimeric RNAs of bovine viral diarrhea virus and hepatitis C virus or encephalomyocarditis virus
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Pinpoints key BVDV 5' NTR elements for replication; leaves open their use in pestivirus vaccines or anti-HCV screening.
Structured PICO
P
Population
Chimeric RNAs of bovine viral diarrhea virus (BVDV) and hepatitis C virus (HCV) or encephalomyocarditis virus (EMCV)
I
Intervention
Replacement of BVDV 5' NTR with HCV or EMCV IRES elements
O
Outcome
Viral replication efficiency and stabilitysurrogate
The study identifies critical cis-acting RNA elements in the BVDV 5' NTR required for efficient replication, which may aid in developing pestivirus vaccines and screening anti-HCV antivirals.
Cite This Study
Frolov et al. (1998) studied this question.