Population
Infectious cDNA clones of bovine viral diarrhea virus (BVDV)
Comparison
Spontaneous and engineered mutations in the 5'… vs Parent virus (wild-type)
Design
Preclinical
Authors
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Ib loop and terminal nucleotides are essential for BVDV infectivity; leaves open their value as antiviral targets pending mammalian validation.
Mutations in the 5' NTR of bovine viral diarrhea virus, particularly in the Ib loop and 5'-terminal nucleotides, significantly impact viral replication and infectivity.
Becher et al. (2000) studied this question.
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