Key result
The 3'V motif of the bovine viral diarrhea virus 3' nontranslated region is required for accurate translation termination, which is essential for efficient viral RNA replication.
Population
Bovine viral diarrhea virus (BVDV) genome/RNA
Design
Preclinical
Authors
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Disruption of the 3'V motif may guide pestivirus antivirals in livestock; leaves open extension to human flaviviruses or therapeutic development.
The 3'V portion of the BVDV 3'NTR coordinates viral translation and replication by ensuring accurate translation termination.
Isken et al. (2004) studied Bovine viral diarrhea virus (BVDV) infection. Genetic studies and structure probing of the 3'V portion of the viral 3' nontranslated region was evaluated on Role of the 3'V motif in viral RNA replication and translation termination. The 3'V motif of the bovine viral diarrhea virus 3' nontranslated region is required for accurate translation termination, which is essential for efficient viral RNA replication.