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July 1, 2005Journal of VirologyOpen Access

Essential and Nonessential Elements in the 3′ Nontranslated Region of Bovine Viral Diarrhea Virus

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Population

Infectious Bovine viral diarrhea virus (BVDV) cDNA clone

Design

Preclinical

Authors

APAlexander PankrazBioScientia (Poland)HTHeinz‐Jürgen ThielJustus-Liebig-Universität GießenPBPaul BecherWilmington College

Discussion

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Implication

SL I may guide pestivirus antiviral design; leaves open translation to clinical or human flaviviruses.

Structured PICO

P
Population
Infectious Bovine viral diarrhea virus (BVDV) cDNA clone
I
Intervention
Introduction of 4-base deletions and deletions of each of the three stem-loops in the 3' nontranslated region (NTR)
O
Outcome
Viral replication (assessed by plaque phenotype, growth kinetics, and synthesis of viral RNA)surrogate

This study maps the essential and nonessential elements within the 3' NTR of BVDV, showing that stem-loop I is indispensable for viral replication.

Cite This Study

Pankraz et al. (2005) studied this question.

synapsesocial.com/papers/6a814226ada1eccddc33aac2https://doi.org/10.1128/jvi.79.14.9119-9127.2005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phenotypic Characterization of Three Phylogenetically Conserved Stem-Loop Motifs in the Mengovirus 3′ Untranslated Region2001 · 38 citations
  2. 2Sequence and Structural Elements at the 3′ Terminus of Bovine Viral Diarrhea Virus Genomic RNA: Functional Role during RNA Replication1999 · 105 citations
  3. 3cis-acting RNA elements required for replication of bovine viral diarrhea virus–hepatitis C virus 5′ nontranslated region chimeras1998 · 73 citations
  4. 4Genetic Analysis of Sequences in the 3′ Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication2002 · 289 citations
  5. 5Serine protease of pestiviruses: determination of cleavage sites1997 · 111 citations