Population
Recombinant bovine viral diarrhea virus (BVDV) nonstructural protein 5B (NS5B) expressed in Escherichia coli
Comparison
Deletion of 24 amino acids at the C terminus and… vs Full-length BVDV NS5B
Design
Preclinical
Authors
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Facilitates biochemical studies of BVDV RdRp; leaves open extension to human flaviviruses or antivirals.
Deletion of the C-terminal hydrophobic domain of BVDV NS5B improves solubility and retains RdRp activity, facilitating further functional analysis of viral RNA replication.
Lai et al. (1999) studied this question.
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