November 1, 1998Journal of VirologyOpen Access

Identification and Characterization of an RNA-Dependent RNA Polymerase Activity within the Nonstructural Protein 5B Region of Bovine Viral Diarrhea Virus

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Population

Bovine viral diarrhea virus (BVDV) NS5B protein derived from an infectious cDNA clone (NADL strain)

Design

Preclinical

Authors

WZWeidong ZhongPrecision for Medicine (United States)LGLester L. GutshallJanssen (Belgium)AVAlfred M. Del VecchioJanssen (Belgium)

Discussion

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Implication

In vitro BVDV NS5B activities inform viral enzyme function; leaves open therapeutic targeting in animal infection models.

Structured PICO

Population

Bovine viral diarrhea virus (BVDV) NS5B protein derived from an infectious cDNA clone (NADL strain)

Intervention

In vitro RNA polymerase assay using homopolymeric RNA or BVDV minigenomic RNA templates

Outcome

RNA-dependent RNA polymerase activity and terminal nucleotidyl transferase activitysurrogate

The study identifies and characterizes the RNA-dependent RNA polymerase and terminal nucleotidyl transferase activities of the BVDV NS5B protein in vitro.

Cite This Study

Zhong et al. (1998) studied this question.

synapsesocial.com/papers/6a7267b9ac440176ef2aa82e https://doi.org/10.1128/jvi.72.11.9365-9369.1998

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Identification and Characterization of an RNA-Dependent RNA Polymerase Activity within the Nonstructural Protein 5B Region of Bovine Viral Diarrhea Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification and Characterization of an RNA-Dependent RNA Polymerase Activity within the Nonstructural Protein 5B Region of Bovine Viral Diarrhea Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider