February 20, 1996Proceedings of the National Academy of SciencesOpen Access

Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus.

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Population

Poliovirus (PV) chimeric genomes

Design

Preclinical

Authors

HLH H LuChinese Preventive Medicine Association EWEckard WimmerCalifornia Institute of Technology

Discussion

Member takes

Implication

Refines HCV IRES requirements in viable chimeras; extends in vivo modeling but leaves open therapeutic translation.

Structured PICO

Population

Poliovirus (PV) chimeric genomes

Intervention

Replacement of PV internal ribosomal entry site (IRES) with genetic elements of hepatitis C virus (HCV), specifically nt 9-332 of the genotype Ib HCV genome with or without 366 nt of the HCV core-encoding sequence

Outcome

Viability and replication phenotype of the chimeric virussurrogate

The bona fide HCV IRES includes genetic information mapping to both the 5'NTR and sequences of the HCV open reading frame, and PV/HCV chimeras can serve as in vivo models for studying HCV IRES function.

Cite This Study

Lu et al. (1996) studied this question.

synapsesocial.com/papers/6a201c7e2065d284090df79d https://doi.org/10.1073/pnas.93.4.1412

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Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider