Population
In vitro translation systems for poliovirion RNA and encephalomyocarditis virion RNA
Comparison
Addition of various components including excess… vs Encephalomyocarditis virion RNA, reoviral RNA…
Design
Preclinical
Authors
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Suggests poliovirus mechanism to reprogram host translation; leaves open whether eIF4A modulation could limit replication.
Poliovirus RNA requires unusually large amounts of eukaryotic initiation factor 4A for optimal translation in vitro, highlighting a mechanism for reprogramming host cell translational machinery.
Daniels-McQueen et al. (1983) studied this question.
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