Key result
Genomic sequencing of the Kor-HAV-F strain identified it as subgenotype IIIA with two unique amino acid changes (T168A and L96P) in the VP1 and 2A regions compared to reference strains.
This study reports the first full-length sequence of a hepatitis A virus isolated in the Republic of Korea, identifying unique amino acid changes in the VP1 and 2A regions.
Hepatitis A virus is known to cause acute hepatitis and has significant implications for public health throughout the world. In the Republic of Korea, the number of patients with hepatitis A virus infection has been increasing rapidly since 2006. In this study, the Kor-HAV-F strain was identified as subgenotype IIIA by RT-PCR, and its identity was confirmed by nucleotide sequencing and alignment analysis. Moreover, detailed phylogenetic analysis indicated that the Kor-HAV-F strain clustered into subgenotype IIIA, including strains isolated in Japan, Norway, and India. The entire amino acid sequence of the VP1 and 2A regions was compared with that of the reference strains isolated in various countries. We found 2 amino acid changes (T168A and L96P, resp.) in the VP1 and 2A regions, which had not been found in any other hepatitis A virus strain. To our knowledge, this study is the first to report the full-length sequence of a hepatitis A virus isolated in the Republic of Korea.
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Lee et al. (2013) studied Hepatitis A virus infection. Genomic sequencing of Kor-HAV-F strain vs. Reference strains was evaluated on Full-length genomic sequence and phylogenetic analysis. Genomic sequencing of the Kor-HAV-F strain identified it as subgenotype IIIA with two unique amino acid changes (T168A and L96P) in the VP1 and 2A regions compared to reference strains.
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